As computing and communication become faster, cheaper, and more readily available in energy-efficient platforms, the potential for advanced capabilities in engineered systems becomes manifest. Cyber-physical systems (CPS) are physical and engineered systems whose operations are monitored, coordinated, controlled, and integrated by computing and communication. The deployment of CPS is profoundly transforming how we interact with the physical world, just as the world wide web transformed how we interact with one another. Further harnessing the capabilities of CPS will have enormous societal and economic impact.